pentobarbital will minimize the extent or influence of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.

Monitor Intently (one)pentobarbital will boost the degree or influence of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

fentanyl transmucosal and pentobarbital the two increase sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom substitute remedy options are inadequate

Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone could maximize and can result in perhaps fatal respiratory depression

Just after stopping a CYP3A4 inducer, as the consequences on the inducer drop, the fentanyl plasma focus will enhance which could improve or prolong each the therapeutic and adverse results.

pentobarbital will lessen the extent or outcome of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.

pentobarbital will lower the level or effect of temsirolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will minimize the level or influence of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will lessen the level or outcome of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Not known.

pentobarbital will reduce the level or effect of lapatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will lessen the level or result of website pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

Monoamine oxidase inhibitors (MAOI) may possibly inhibit barbiturate metabolism and extend barbiturate outcomes; observe intently

pentobarbital will reduce the extent or influence of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not advised; sturdy cytochrome P450 enzyme inducers minimize systemic exposure to roflumilast and may decrease the therapeutic performance

Therapy need to be administered with caution, if in any respect, to individuals that are mentally frustrated, have suicidal tendencies, or history of drug abuse